The principal driver of the increase in spending was personnel-related expenses. Net reduction for the third quarter of 2010 was $18.6 million, or $0.60 per common share , weighed against $13.8 million, or $8.56 per common share, for the 3rd quarter of 2009 . The difference in the amount of weighted typical shares outstanding mainly resulted from AVEO’s preliminary public offering in March 2010, as well as the conversion of all preferred stock to common stock. Recent Advancements Completed Enrollment of TIVO-1: In August, AVEO announced that it attained its enrollment target for TIVO-1 in sufferers with advanced renal cell carcinoma .It is intended to help laboratories manage their raising vitamin D testing volumes through the quantitative perseverance of 25-hydroxy supplement D in individual serum and plasma to aid in the evaluation of vitamin D sufficiency. 25-hydroxy vitamin D is the body’s repository of vitamin D and is established as the correct measurable indicator of supplement D status. Low supplement D can cause skeletal disorders also, such as rickets in osteopenia and kids in adults, and has been associated with an increased threat of hip fractures. According to the Institute of Medicine of the National Academy of Technology, most adults should get 600 international products of supplement D daily instead of the previously recommended 400 IUs.