Furthermore, they look like independent of eosinophil recruitment into the airways, since, based on the particular markers we chose, the redesigning changes evident following the allergen problem were comparable to those seen after the methacholine challenge . These findings have got implications for the administration of asthma, since airway redesigning has been associated with a decline in lung function and the increased loss of bronchodilator reversibility.24 Currently, the principal aim of asthma administration is to lessen symptoms and control the condition by targeting airway irritation.The researchers found that the mice's symptoms improved after they received AT2101 for four weeks. The researchers also observed that AT2101 was effective in treating Parkinson's in mice despite the fact that they did not carry a mutant edition of the Gaucher gene, suggesting that the compound may have a clinical impact in the broader Parkinson's people. This was the first time a pharmacological chaperone demonstrated promise in a style of Parkinson's, according to Chesselet. Parkinson's disease affects as many as 1 million Us citizens, and 60,000 new cases are diagnosed each full year.