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The right hilar lymph-node mass and spleen, which were not the mark of radiotherapy, received only low, nontherapeutic doses of radiation , further helping the notion that disease regression at these distant sites was because of an enhanced systemic response. Delayed responses happening 18 to 20 weeks after ipilimumab treatment are popular, yet inside our opinion, the 19-month interval between your begin of ipilimumab and disease response, with radiotherapy having been administered in the interim, is more supportive of an abscopal impact.